Generally, this disclosure describes systems (and methods) for moderating interrupts in a virtualization environment. An overflow interrupt interval is defined. The overflow interrupt interval is used for triggering activation of an inactive guest so that the guest may respond to a critical event. The guest, including a network application, may be active for a first time interval and inactive for a second time interval. A latency interrupt interval may be defined. The latency interrupt interval is configured for interrupt moderation when the network application associated with a packet flow is active, i.e., when the guest including the network application is active on a processor. Of course, many alternatives, variations, and modifications are possible without departing from this embodiment.