Various embodiments of communication systems and methods in which the communication system is operative to find, record, and use sets of pre-distortion parameters in conjunction with a pre-distortion procedure, in which each said set of pre-distortion parameters is operative to specifically counter distortions produced in a power amplifier by a specific combination of level of input signal power and level of analog gain associated with a transmission path of the communication system. In some embodiments, there is a modulator, a transmission chain, a distortion analysis mechanism, and a pre-distortion mechanism, operative to analyze and modify signals so as to counter signal distortion.