Invention Grant
US09180122B2 5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain
有权
5-或6-取代的3-羟基-2（1H） - 吡啶酮作为D-氨基酸氧化酶（DAAO）抑制剂治疗精神分裂症，认知障碍和疼痛等疾病
- Patent Title: 5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain
- Patent Title (中): 5-或6-取代的3-羟基-2（1H） - 吡啶酮作为D-氨基酸氧化酶（DAAO）抑制剂治疗精神分裂症，认知障碍和疼痛等疾病
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Application No.: US14131343Application Date: 2012-07-05
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Publication No.: US09180122B2Publication Date: 2015-11-10
- Inventor: William Farnaby , Charlotte Fieldhouse , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller , Katherine Hazel
- Applicant: William Farnaby , Charlotte Fieldhouse , Catrina Kerr , Natasha Kinsella , David Livermore , Kevin Merchant , David Miller , Katherine Hazel
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: GB1111704.1 20110707
- International Application: PCT/GB2012/000574 WO 20120705
- International Announcement: WO2013/004996 WO 20130110
- Main IPC: A61K31/4412
- IPC: A61K31/4412 ; A61K31/444 ; A61K31/497 ; A61K45/06 ; C07D213/69 ; C07D213/70 ; C07D213/71 ; C07D401/12 ; C07D413/12
Abstract:
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or fluorine, one of A and B is R2, the other is a group —X—Y—R3. R3 represents a carbocyclic or heterocyclic ring. Further variables are as defined in the specification. Also claimed are—processes for their preparation, pharmaceutical compositions containing them and their use in therapy of diseases such as schizophrenia, cognitive disorders and pain by modulating the D-amino acid oxidase enzyme (DAAO).
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