A method and system for analyzing and retrieving breast tissue abnormality tracking data, providing a tool for a radiologist that includes a report summarizing the statistical frequency of diagnosed patients, both locally and nationally, with breast tissue region-of-interest classifications similar to the breast tissue images taken of the anatomy of an individual patient. In one embodiment, a computer aided diagnostic program can be tested or verified against the breast tissue images and the region-of-interest classifications that have been validated by definitive patient diagnosis. Another embodiment allows the efficient collection of all of the breast tissue abnormalities for a given medical facility in order to provide trending data or radiologist performance analysis. In yet another embodiment, the region-of-interest abnormalities in a single location in a patient's tissue are correlated across a variety of imaging modalities including X-rays, mammogram, CT, ultrasound, MRI, or other imaging technologies. In another embodiment, the region-of-interest feature descriptors based on a location of an abnormality can be correlated by features and images for a plurality of imaging modalities as well as the pathological outcome.