Provided is an isotope delivery system and a method for irradiating a target and delivering the target to an extraction point. The isotope delivery system may include a cable including at least one target for irradiation, a drive system configured for moving the cable, and a first guide configured to guide the cable for insertion and extraction from a nuclear reactor. The method for irradiating a target and delivering a target may include pushing a cable with an attached target through a first guide and into a nuclear reactor using a drive system, irradiating the target in the nuclear reactor, pulling the cable with the attached irradiated target towards the drive system, pushing the cable with the irradiated target towards a loading/unloading area using the drive system, and placing the irradiated target into a transfer cask, wherein the cable is pulled and pushed by the drive system.