An exemplary method of providing network address translation (NAT) for GPRS tunneling protocol user plane (or GTP-U) traffic on a data center server supporting multiple radio bearers in a mobile network is disclosed. The method includes: receiving packets from a source node via a GTP-U tunnel; filtering ingress GTP-U packets from other types of packets; forwarding a respective ingress GTP-U packet with a public destination IP address to a first queue if a destination IP address matches a defined GTP-U public IP address for the destination node; extracting one or more ingress GTP-U packets and forwarding the packets to a user-land operating system process for inspection; performing NAT of the destination IP address; placing ingress GTP-U packets that have an internal IP address that identifies with a particular radio bearer into a second queue; and forwarding the ingress GTP-U packets via a radio bearer within a network for processing.