Features are disclosed for generating text-to-speech (TTS) audio programs from textual content received from multiple sources. A TTS system may assemble an audio program from several individual audio presentations of user-selected network-accessible content. Users may configure the TTS system to retrieve personal content as well as publically accessible content. The audio program may include segues, introductions, summaries, and the like. Voices may be selected for individual content items based on user selections or on characteristics of the content or content source.