A wireless base station having K antennas communicates with M mobile devices using multiuser diversity scheme with opportunistic interference management. The base station transmits K distinct pilot signals from K corresponding antennas and receives feedback from mobile devices. The feedback from each device indicates a strong pilot signal and a weak pilot signal received from the K distinct pilot signals. Using these indications, the base station assigns each of the K antennas to a mobile device. The base station then transmits distinct data streams to the mobile devices using the corresponding antennas assigned to the corresponding mobile devices. The transmission may include multiplying the transmitted distinct data streams by a vector V orthogonal to a vector U, thereby allowing mobile devices not assigned to an antenna to cancel the transmitted distinct data streams.