Clipping is provided for volume rendering in three-dimensional medical imaging. Rather than a single or even two clipping planes, an enclosed clipping volume isolates a region of interest. More than one volume rendering may be formed from the data of the clipping volume. The volume renderings from different directions, such as opposite directions, may be displayed substantially simultaneously. For imaging a valve or other structure with multiple views of interest, the clipping volume defines the valve or structure region and rendering from the multiple views provides desired diagnosis information.