Invention Grant
- Patent Title: Dual-acting benzoimidazole antihypertensive agents
- Patent Title (中): 双效苯并咪唑抗高血压药
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Application No.: US14132391Application Date: 2013-12-18
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Publication No.: US09198899B2Publication Date: 2015-12-01
- Inventor: Paul Allegretti , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant: Paul Allegretti , Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Darren McMurtrie , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah
- Main IPC: C07D235/08
- IPC: C07D235/08 ; A61K31/4184 ; C07D401/12 ; C07D403/10 ; C07D403/12 ; C07D405/12 ; A61K31/4439 ; A61K31/5377 ; A61K45/06 ; C07D405/10
Abstract:
The invention is directed to compounds having the formula: wherein: Ar, r, n, X, R2-3 and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20140107120A1 DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2014-04-17
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