Invention Grant
US09198926B2 Methods and compositions comprising rifabutin, clarithromycin, and clofazimine
有权
包括利福布丁,克拉霉素和氯法齐明的方法和组合物
- Patent Title: Methods and compositions comprising rifabutin, clarithromycin, and clofazimine
- Patent Title (中): 包括利福布丁,克拉霉素和氯法齐明的方法和组合物
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Application No.: US14271758Application Date: 2014-05-07
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Publication No.: US09198926B2Publication Date: 2015-12-01
- Inventor: Thomas Julius Borody , Patrick Gosselin
- Applicant: Red Hill Biopharma Ltd.
- Applicant Address: IL Tel-Aviv
- Assignee: RedHill Biopharma Ltd.
- Current Assignee: RedHill Biopharma Ltd.
- Current Assignee Address: IL Tel-Aviv
- Agency: Greenberg Traurig, LLP
- Main IPC: A61K39/04
- IPC: A61K39/04 ; A61K31/7048 ; A61P31/04 ; A61K31/395 ; A61K31/498 ; A61K31/44 ; A61K31/438 ; A61K31/435

Abstract:
A composition of the present invention comprises an effective amount of rifabutin, an effective amount of clarithromycin, an effective amount of clofazimine, and an effective amount of an absorption enhancer, wherein the effective amount of the absorption enhancer is sufficient so that, when the composition is administered to a patient, an overall metabolism of clarithromycin as caused by rifabutin is reduced by shifting competing metabolism of rifabutin and clarithromycin so as to result in more active clarithromycin.
Public/Granted literature
- US20140243279A1 METHODS AND COMPOSITIONS COMPRISING RIFABUTIN, CLARITHROMYCIN, AND CLOFAZIMINE Public/Granted day:2014-08-28
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