Invention Grant
- Patent Title: Recombinant bacterium comprising a toxin/antitoxin system
- Patent Title (中): 包含毒素/抗毒素系统的重组细菌
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Application No.: US13989692Application Date: 2011-11-22
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Publication No.: US09198950B2Publication Date: 2015-12-01
- Inventor: Melha Mellata
- Applicant: Melha Mellata
- Applicant Address: US AZ Tempe
- Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee Address: US AZ Tempe
- Agency: Polsinelli PC
- Agent Rebecca C. Riley-Vargas
- International Application: PCT/US2011/061896 WO 20111122
- International Announcement: WO2012/087483 WO 20120628
- Main IPC: A61K39/112
- IPC: A61K39/112 ; A61K39/02 ; A61K49/00 ; A61K38/16 ; C12N1/38 ; C12N15/74 ; A61K39/00
Abstract:
The present invention encompasses recombinant bacteria suitable for live attenuated vaccines, and methods of use thereof. One aspect of the present invention encompasses a recombinant Salmonella bacterium. The bacterium comprises a first promoter operably linked to a nucleic acid encoding a toxin and a second promoter operably linked to a nucleic acid encoding an antitoxin, wherein the second promoter is inactive in vivo, but active in vitro.
Public/Granted literature
- US20130337013A1 RECOMBINANT BACTERIUM COMPRISING A TOXIN/ANTITOXIN SYSTEM Public/Granted day:2013-12-19
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