Invention Grant
- Patent Title: B-type plexin antagonists and uses thereof
- Patent Title (中): B型plexin拮抗剂及其用途
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Application No.: US13983715Application Date: 2012-02-09
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Publication No.: US09198966B2Publication Date: 2015-12-01
- Inventor: Stefan Offermanns , Jakub Swiercz , Thomas Worzfeld
- Applicant: Stefan Offermanns , Jakub Swiercz , Thomas Worzfeld
- Applicant Address: DE Heidelberg DE Munich
- Assignee: Ruprecht-Karls-Universität Heidelberg,Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- Current Assignee: Ruprecht-Karls-Universität Heidelberg,Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- Current Assignee Address: DE Heidelberg DE Munich
- Agency: Foley & Lardner LLP
- Priority: EP11153784 20110209
- International Application: PCT/EP2012/052238 WO 20120209
- International Announcement: WO2012/107531 WO 20120816
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K39/395 ; A61K31/713 ; C07K16/30 ; C12N15/113 ; A61K31/7088 ; A61K38/02 ; G01N33/50
Abstract:
The present invention concerns the field of cancer therapy. In particular, it relates to an antagonist of a B-type plexin which prevents the interaction of the B-type plexin with ErbB-2 for use as a medicament, in particular, for treating metastasizing cancer. The present invention also contemplates a method for identifying an antagonist which prevents the interaction of a B-type plexin with ErbB-2. Finally, the invention provides for a polynucleotide encoding a B-type plexin polypeptide which lacks a functional intracellular domain and the said polypeptide.
Public/Granted literature
- US20140044741A1 B-TYPE PLEXIN ANTAGONISTS AND USES THEREOF Public/Granted day:2014-02-13
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