Invention Grant
- Patent Title: Monomers and oligonucleotides comprising cycloaddition adduct(s)
- Patent Title (中): 包含环加成加合物的单体和寡核苷酸
-
Application No.: US13575461Application Date: 2011-01-28
-
Publication No.: US09198972B2Publication Date: 2015-12-01
- Inventor: Muthiah Manoharan , Narayanannair K. Jayaprakash , Kallanthottahil G. Rajeev , Michael E. Jung
- Applicant: Muthiah Manoharan , Narayanannair K. Jayaprakash , Kallanthottahil G. Rajeev , Michael E. Jung
- Applicant Address: US MA Cambridge
- Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: LeClairRyan
- Agent Jeffrey N. Townes
- International Application: PCT/US2011/022975 WO 20110128
- International Announcement: WO2011/100131 WO 20110818
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04 ; A61K47/48 ; C07D249/16 ; C07D471/04 ; C07D487/04 ; C07D493/04 ; C07D493/08 ; C07D495/04 ; C07D495/08 ; C07F9/572 ; C07F9/655 ; C07F9/6558 ; C07H19/067
Abstract:
The invention features compounds of formula (V) or (XII). In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.
Public/Granted literature
- US20130053334A1 MONOMERS AND OLIGONUCLEOTIDES COMPRISING CYCLOADDITION ADDUCT(S) Public/Granted day:2013-02-28
Information query
