Invention Grant
- Patent Title: PAMAM, spacer molecule and cafestol polymers
- Patent Title (中): PAMAM,间隔分子和咖啡酚聚合物
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Application No.: US13919403Application Date: 2013-06-17
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Publication No.: US09198973B2Publication Date: 2015-12-01
- Inventor: Leonardo S. Santos , John Amalraj , Esteban F. Duran Lara , Fabiane M. Nachtigall
- Applicant: Fundación Fraunhofer Chile Research , Universidad de Talca
- Applicant Address: CL CL
- Assignee: Fundacion Fraunhofer Chile Research,Universidad de Talca
- Current Assignee: Fundacion Fraunhofer Chile Research,Universidad de Talca
- Current Assignee Address: CL CL
- Agency: Merchant & Gould P.C.
- Main IPC: A61K47/00
- IPC: A61K47/00 ; C08L77/00 ; C08L79/00 ; A61K47/48 ; C08L79/02

Abstract:
The present invention is directed to a polymeric compound with a size in a nanometric scale, useful as a biocompatible carrier for the transport and delivery of active agents into a fish, insect, animal, reptile, bird, human, or plant, wherein said polymeric compound comprises PAMAM (polyamidoamine) dendrimers, a spacer molecule, and cafestol, wherein the polymeric compound of the invention comprises a structure of the kind (cafestol-PAMAM derivative)2-spacer molecule. Use of the compound as a biocompatible carrier for transport and delivery of antithrombotic active agents is disclosed. Procedures for obtaining a polymeric compound comprising the activation of cafestol, activation of polyethylene glycol, and formation of cafestol-PAMAM-PEG-PAMAM-cafestol are also disclosed.
Public/Granted literature
- US20140371401A1 PAMAM, SPACER MOLECULE AND CAFESTOL POLYMERS Public/Granted day:2014-12-18
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