Invention Grant
- Patent Title: Aryl-quinoline derivatives
- Patent Title (中): 芳基 - 喹啉衍生物
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Application No.: US13666202Application Date: 2012-11-01
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Publication No.: US09199938B2Publication Date: 2015-12-01
- Inventor: Simona M. Ceccarelli , Aurelia Conte , Holger Kuehne , Bernd Kuhn , Werner Neidhart , Ulrike Obst Sander , Markus Rudolph
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Nutley
- Priority: EP11187967 20111104
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D401/14 ; C07D215/54 ; C07D401/04 ; C07D413/04 ; C07D215/227 ; C07D215/00 ; C07D215/02 ; C07D491/048

Abstract:
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
Public/Granted literature
- US20130116234A1 ARYL-QUINOLINE DERIVATIVES Public/Granted day:2013-05-09
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