Invention Grant
- Patent Title: Quinoline amide M1 receptor positive allosteric modulators
- Patent Title (中): 喹啉酰胺M1受体阳性变构调节剂
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Application No.: US13515724Application Date: 2010-12-13
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Publication No.: US09199939B2Publication Date: 2015-12-01
- Inventor: Scott D. Kuduk , Kelly-Ann S. Schlegel , Zhi-Qiang Yang
- Applicant: Scott D. Kuduk , Kelly-Ann S. Schlegel , Zhi-Qiang Yang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Tadaro
- International Application: PCT/US2010/060007 WO 20101213
- International Announcement: WO2011/084368 WO 20110714
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D215/48 ; C07D215/60 ; C07D409/14 ; C07D413/06 ; C07D405/12 ; C07D401/14 ; C07D413/14 ; C07D405/14 ; C07D417/14
Abstract:
The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20120252808A1 QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Public/Granted day:2012-10-04
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