Invention Grant
US09200009B2 Polycyclic pyridone derivative having integrase inhibitory activity
有权
具有整合酶抑制活性的多环吡啶酮衍生物
- Patent Title: Polycyclic pyridone derivative having integrase inhibitory activity
- Patent Title (中): 具有整合酶抑制活性的多环吡啶酮衍生物
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Application No.: US14351110Application Date: 2012-10-12
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Publication No.: US09200009B2Publication Date: 2015-12-01
- Inventor: Toshiyuki Akiyama
- Applicant: Shionogi & Co., Ltd.
- Applicant Address: JP Osaka-Shi, Osaka
- Assignee: SHIONOGI & CO., LTD.
- Current Assignee: SHIONOGI & CO., LTD.
- Current Assignee Address: JP Osaka-Shi, Osaka
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Yang Xu
- Priority: JP2011-224467 20111012
- International Application: PCT/JP2012/076386 WO 20121012
- International Announcement: WO2013/054862 WO 20130418
- Main IPC: C07D498/14
- IPC: C07D498/14 ; A61K31/4985 ; A61K31/437 ; C07D471/22
Abstract:
The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
Public/Granted literature
- US20140256937A1 POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY Public/Granted day:2014-09-11
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