Invention Grant
- Patent Title: Bifunctional compounds
- Patent Title (中): 双功能化合物
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Application No.: US14352891Application Date: 2012-10-19
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Publication No.: US09200035B2Publication Date: 2015-12-01
- Inventor: Peter Wipf , Joel S. Greenberger , Michael W. Epperly , Melissa M. Sprachman , Julie Pamela Goff
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2012/061109 WO 20121019
- International Announcement: WO2013/059651 WO 20130425
- Main IPC: A61K38/06
- IPC: A61K38/06 ; A61K38/07 ; C07K5/087 ; C07D405/14 ; C07D405/12 ; C07D305/06 ; C07K5/065 ; C07D205/04

Abstract:
A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy group or an aryloxy group when R1 or R3 is O and R8 is not a C1-C3 alkoxy group or an aryloxy group when R5 or R7 is O; R9, R10, R11 and R12 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group.
Public/Granted literature
- US20140256654A1 BIFUNCTIONAL COMPOUNDS Public/Granted day:2014-09-11
Information query
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