Invention Grant
- Patent Title: Anti-cocaine compositions and treatment
- Patent Title (中): 抗可卡因组合物和治疗
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Application No.: US13676324Application Date: 2012-11-14
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Publication No.: US09200265B2Publication Date: 2015-12-01
- Inventor: Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
- Applicant: The Trustees of Columbia University in the City of New York , The Regents of the University of Michigan , The University of Kentucky Research Foundation
- Applicant Address: US NY New York US MI Ann Arbor US KY Lexington
- Assignee: The Trustees of Columbia University in the City of New York,The Regents of the University of Michigan,University of Kentucky Research Foundation
- Current Assignee: The Trustees of Columbia University in the City of New York,The Regents of the University of Michigan,University of Kentucky Research Foundation
- Current Assignee Address: US NY New York US MI Ann Arbor US KY Lexington
- Agency: Dentons US LLP
- Main IPC: A61K38/46
- IPC: A61K38/46 ; A61K38/43 ; C12N9/18 ; C12N9/16 ; C12N9/14 ; C12P21/06 ; C12P19/34 ; C07H21/04 ; C07K1/00 ; A61K38/00
Abstract:
Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
Public/Granted literature
- US20130136728A1 ANTI-COCAINE COMPOSITIONS AND TREATMENT Public/Granted day:2013-05-30
Information query
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