Invention Grant
US09200284B2 Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
有权
通过不对称双链RNA特异性抑制KRAS的方法和组合物
- Patent Title: Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
- Patent Title (中): 通过不对称双链RNA特异性抑制KRAS的方法和组合物
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Application No.: US13738024Application Date: 2013-01-10
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Publication No.: US09200284B2Publication Date: 2015-12-01
- Inventor: Bob D. Brown
- Applicant: Dicerna Pharmaceuticals, Inc.
- Applicant Address: US MA Watertown
- Assignee: Dicerna Pharmaceuticals, Inc.
- Current Assignee: Dicerna Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Edwards Wildman Palmer LLP
- Agent Christopher R. Cowles
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113
Abstract:
This invention relates to compounds, compositions, and methods useful for reducing KRAS target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA) agents possessing asymmetric end structures.
Public/Granted literature
- US20130123342A1 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF KRAS BY ASYMMETRIC DOUBLE-STRANDED RNA Public/Granted day:2013-05-16
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