A vertical wall mount system is provided that is easily installed in a perfectly level and plumb manner and is further cable of being design to be completely waterproof, interchangeable and customizable to include endless additional features. The vertical wall mount system includes two main components: a sub-frame assembly and a panel frame assembly. The sub-frame assembly includes mounting clips for pivotal attachment to a wall frame, such as, a standard 2×4 stud. Horizontal wall rails are mounted on the mounting clips to create the sub-frame assembly. The horizontal wall rails are designed to support a panel assembly on the horizontal wall rails, which may, for example, include a tile panel. The panel assembly includes a panel frame secured to the back side of the panel, which panel assembly is designed to hang on the horizontal wall rails of the sub-frame assembly.