Invention Grant
- Patent Title: Transgenic mouse model expressing amyloid β 4-42 peptide
- Patent Title (中): 表达淀粉样蛋白的转基因小鼠模型 4-42肽
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Application No.: US13702390Application Date: 2010-06-08
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Publication No.: US09204623B2Publication Date: 2015-12-08
- Inventor: Thomas Bayer , Oliver Wirths
- Applicant: Thomas Bayer , Oliver Wirths
- Applicant Address: DE Gottingen
- Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN
- Current Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS, UNIVERSITÄTSMEDIZIN
- Current Assignee Address: DE Gottingen
- Agency: Lando & Anastasi, LLP
- International Application: PCT/EP2010/058024 WO 20100608
- International Announcement: WO2011/154037 WO 20111215
- Main IPC: A01K67/00
- IPC: A01K67/00 ; G01N33/00 ; A01K67/027 ; C07K14/47 ; C12N15/85
Abstract:
The present invention describes a novel transgenic mouse model for the common sporadic form of Alzheimer's disease. More particularly, the invention relates to a nucleotide sequence encoding Aβ 4-42 in functional linkage with at least a promoter, signal peptide sequence and a polyadenylation signal sequence, a cell and a transgenic non-human animal comprising said nucleotide sequence, and their respective use in screening methods.
Public/Granted literature
- US20130179998A1 TRANSGENIC MOUSE MODEL EXPRESSING AMYLOID BETA 4-42 PEPTIDE Public/Granted day:2013-07-11
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