Invention Grant
- Patent Title: Method for treatment of castration-resistant prostate cancer
- Patent Title (中): 抗阉割前列腺癌的治疗方法
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Application No.: US14560673Application Date: 2014-12-04
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Publication No.: US09205102B2Publication Date: 2015-12-08
- Inventor: Martin E. Gleave , Joseph Ischia
- Applicant: The University of British Columbia
- Applicant Address: CA Vancouver
- Assignee: The University of British Columbia
- Current Assignee: The University of British Columbia
- Current Assignee Address: CA Vancouver
- Agency: Larson & Anderson, LLC
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04 ; C07H21/02 ; A61K31/713 ; A61K45/06 ; A61K31/4166 ; A61K31/712
Abstract:
Castrate resistant prostate cancer cell lines exhibiting resistance to the androgen-receptor antagonist enzaluatamide overexpress one or both of IGFBP-2 or IGFBP-5 when compared to non-resistant cell lines. Oligonucleotides that target IGFBP-2 and IGFBP-5 can be used to overcome this resistance or as part of a treatment program when administered concurrently with the administration of androgen-receptor antagonist treatments.
Public/Granted literature
- US20150157656A1 Method for Treatment of Castration-Resistant Prostate Cancer Public/Granted day:2015-06-11
Information query
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