Invention Grant
- Patent Title: Clean method for preparing D,L-methionine
- Patent Title (中): 清洁方法制备D,L-甲硫氨酸
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Application No.: US14425310Application Date: 2013-01-06
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Publication No.: US09206120B2Publication Date: 2015-12-08
- Inventor: Zhirong Chen , Cunchao Wang , Chuqiu Zhao , Sujuan Wang , Chengfeng Zhang , Tao Long , Xinhong Liu
- Applicant: ZHEJIANG NHU COMPANY LTD. , ZHEJIANG UNIVERSITY , SHANDONG NHU AMINO ACIDS CO., LTD.
- Applicant Address: CN Shaoxing CN Hangzhou CN Weifang
- Assignee: ZHEJIANG NHU COMPANY LTD.,ZHEJIANG UNIVERSITY,SHANDONG NHU AMINO ACIDS CO., LTD.
- Current Assignee: ZHEJIANG NHU COMPANY LTD.,ZHEJIANG UNIVERSITY,SHANDONG NHU AMINO ACIDS CO., LTD.
- Current Assignee Address: CN Shaoxing CN Hangzhou CN Weifang
- Agent Jiwen Chen
- Priority: CN201210320297 20120903
- International Application: PCT/CN2013/070129 WO 20130106
- International Announcement: WO2014/032401 WO 20140306
- Main IPC: C07C323/00
- IPC: C07C323/00 ; C07C321/00 ; C07C45/00 ; C07C319/20 ; C07D207/38

Abstract:
The present invention discloses a clean method for preparing a D,L-methionine comprising the steps of: preparing a potassium cyanide solution using a crystallized mother solution containing potassium carbonate as an absorbing liquid to absorb hydrocyanic acid, then reacting the potassium cyanide solution with 3-methylthio propionaldehyde and an ammonium bicarbonate solution at 50-150° C. for 3-15 minutes so as to obtain a 5-(β-methylthioethyl)glycolyurea solution, then bring the 5-(β-methylthioethyl)glycolyurea solution to a temperature of 140-220° C. and subjecting to a saponification reaction for 2-5 minutes, after the completion of the saponification, reducing the temperature to 0-40° C., extracting with an organic solvent, neutralizing the water phase with CO2 and crystallizing, then filtering, washing, and drying to obtain an acceptable D,L-methionine product; bring the crystallized D,L-methionine mother solution from filtration to a temperature to 110-160° C. to remove CO2, which are all then circulated and used as a hydrocyanic acid-absorbing liquid. The process route of the present invention is a route suitable for a continuous and clean production, substantially without producing waste water and waste gas.
Public/Granted literature
- US20150284323A1 CLEAN METHOD FOR PREPARING D,L-METHIONINE Public/Granted day:2015-10-08
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