Invention Grant
US09206177B2 Substituted dimeric quinazoline-2,4-diones as FGF receptor agonists
有权
取代的二聚喹唑啉-2,4-二酮作为FGF受体激动剂
- Patent Title: Substituted dimeric quinazoline-2,4-diones as FGF receptor agonists
- Patent Title (中): 取代的二聚喹唑啉-2,4-二酮作为FGF受体激动剂
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Application No.: US14369144Application Date: 2012-12-26
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Publication No.: US09206177B2Publication Date: 2015-12-08
- Inventor: Alexandre Benazet , Nathalie Guillo
- Applicant: Sanofi
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: FR1162486 20111228
- International Application: PCT/IB2012/057726 WO 20121226
- International Announcement: WO2013/098763 WO 20130704
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/96 ; C07D471/04 ; C07D519/00
Abstract:
The invention relates to novel heterocyclic compounds which are pyrazolopyridine derivatives that induce FGFR dimerization, having the general formula: M-L-M2 in which M and M2, which may be identical or different, each represent, independently of one another, a monomer unit M and L represents a linker group which links M1 and M2 covalently with the monomer unit which follows (Formula M). Process for the preparation thereof and therapeutic use thereof.
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