Invention Grant
US09206201B2 Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
有权
含有作为P13K-α和/或bgr的抑制剂的含硼酸的脂质体化合物
- Patent Title: Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
- Patent Title (中): 含有作为P13K-α和/或bgr的抑制剂的含硼酸的脂质体化合物
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Application No.: US14385808Application Date: 2013-03-18
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Publication No.: US09206201B2Publication Date: 2015-12-08
- Inventor: Ram Asrey Vishwakarma , Sanghapal Damodhar Sawant , Parvinder Pal Singh , Abid Hamid Dar , Parduman Raj Sharma , Ajit Kumar Saxena , Amit Nargotra , Anjaneya Aravind Kumar Kolluru , Ramesh Mudududdla , Asif Khurshid Qazi , Aashiq Hussain , Nayan Chanauria
- Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Applicant Address: IN
- Assignee: Counsel of Scientific & Industrial Research
- Current Assignee: Counsel of Scientific & Industrial Research
- Current Assignee Address: IN
- Agency: McDonald Hopkins LLC
- Priority: IN0794/DEL/2012 20120319
- International Application: PCT/IN2013/000169 WO 20130318
- International Announcement: WO2013/140417 WO 20130926
- Main IPC: C07F5/02
- IPC: C07F5/02 ; A61K31/69
Abstract:
Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.
Public/Granted literature
- US20150051173A1 BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF P13K- a AND/OR B Public/Granted day:2015-02-19
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