Invention Grant
- Patent Title: Process for preparing high purity ursodeoxycholic acid
- Patent Title (中): 制备高纯度熊去氧胆酸的方法
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Application No.: US14418296Application Date: 2013-07-30
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Publication No.: US09206220B2Publication Date: 2015-12-08
- Inventor: Massimo Ferrari , Fabrizio Zinetti
- Applicant: ERREGIERRE S.P.A.
- Applicant Address: IT San Paolo d'Argon
- Assignee: Erregierre S.p.A.
- Current Assignee: Erregierre S.p.A.
- Current Assignee Address: IT San Paolo d'Argon
- Agency: Ohlandt, Greeley, Ruggiero & Perle, L.L.P.
- Priority: ITM12012A1344 20120731
- International Application: PCT/EP2013/066002 WO 20130730
- International Announcement: WO2014/020024 WO 20140206
- Main IPC: C07J9/00
- IPC: C07J9/00 ; C07J75/00
Abstract:
The present invention describes a process for the synthesis of ursodeoxycholic acid wherein the purification of the crude ursodeoxycholic acid (containing approximately 13-15% of chenodeoxycholic acid impurity) takes place first passing through a salification with imidazole and a subsequent purification via “methyl ester”, which allows a finished product with an extremely low content of known “cheno and “litho” impurities to be obtained. The present invention also describes the recovery steps of cholic acid and 3α-hydroxy-7-ketocholanic acid from the mother liquors of process intermediates.
Public/Granted literature
- US20150291651A1 PROCESS FOR PREPARING HIGH PURITY URSODEOXYCHOLIC ACID Public/Granted day:2015-10-15
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