Invention Grant
- Patent Title: Modified prokaryotic ubiquitin-like protein and methods of use thereof
- Patent Title (中): 改良的原核泛素样蛋白及其使用方法
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Application No.: US13875599Application Date: 2013-05-02
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Publication No.: US09206241B2Publication Date: 2015-12-08
- Inventor: Katerina Heran Darwin , Nicolaas Sebastiaan Merkx , Huib Ovaa
- Applicant: Katerina Heran Darwin , Nicolaas Sebastiaan Merkx , Huib Ovaa
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Klauber & Jackson LLC
- Main IPC: C07K14/35
- IPC: C07K14/35 ; C12Q1/18

Abstract:
Methods for making and using substrates of deamidase of prokaryotic ubiquitin-like protein (Dop) are described herein. More particularly, modified prokaryotic ubiquitin-like protein (Pup) and functional fragments thereof that serve as exemplary Dop substrates are described and encompassed herein. Screening methods to identify modulators of Dop and Pup activity and use of modulators identified thereby are also described. Methods of using modulators that are identified as inhibitors of Dop and Pup activity for treating diseases/conditions associated with Mycobacterium tuberculosis (Mtb) infection, such as tuberculosis and leprosy, are also envisioned.
Public/Granted literature
- US20130295595A1 MODIFIED PROKARYOTIC UBIQUITIN-LIKE PROTEIN AND METHODS OF USE THEREOF Public/Granted day:2013-11-07
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