Invention Grant
US09206246B2 Heparin/heparan sulfate-dependent inhibitors of activated protein C and uses thereof in treating hemophilic disorders
有权
活化蛋白C的肝素/硫酸乙酰肝素依赖性抑制剂及其在治疗嗜血性疾病中的用途
- Patent Title: Heparin/heparan sulfate-dependent inhibitors of activated protein C and uses thereof in treating hemophilic disorders
- Patent Title (中): 活化蛋白C的肝素/硫酸乙酰肝素依赖性抑制剂及其在治疗嗜血性疾病中的用途
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Application No.: US14081427Application Date: 2013-11-15
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Publication No.: US09206246B2Publication Date: 2015-12-08
- Inventor: Inn-Ho Tsai , An-Chun Cheng
- Applicant: Academia Sinica
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/00 ; C07K14/81 ; C07K14/46
Abstract:
Methods for inhibiting activated protein C (APC) comprising contacting the APC with a Kunitz polypeptide in an amount effective in inhibiting the activity of APC, wherein the Kunitz polypeptide comprises six cysteine residues at positions corresponding to positions 7, 16, 32, 40, 53, and 57 in SEQ ID NO:1, a motif X1GX2CBX′ at positions corresponding to positions 13-18 in SEQ ID NO:1, wherein each of X1 and X2, independently, is any amino acid residue, B is a basic amino acid residue, and X′ is G, A, or V; and at least one heparin-binding motif, which can present at the C-terminus of the Kunitz polypeptide.
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