Invention Grant
US09206426B2 Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof
有权
RNA结合蛋白hnRNPA1，hnRNPA2和PTB的抑制RNA及其用途
- Patent Title: Inhibitory RNAs to RNA binding proteins hnRNPA1, hnRNPA2 and PTB and uses thereof
- Patent Title (中): RNA结合蛋白hnRNPA1，hnRNPA2和PTB的抑制RNA及其用途
-
Application No.: US13582921Application Date: 2011-03-07
-
Publication No.: US09206426B2Publication Date: 2015-12-08
- Inventor: James L. Manley , Mo Chen , Charles David , Jian Zhang
- Applicant: James L. Manley , Mo Chen , Charles David , Jian Zhang
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- International Application: PCT/US2011/027430 WO 20110307
- International Announcement: WO2011/109823 WO 20110909
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/7105 ; A61K31/713 ; C12Q1/68
Abstract:
Provided herein are methods to reduce or slow down cell growth, for example in a cancer cell comprising contacting a cell with an effective amount of a combination of inhibitory RNA molecules targeting hnRNPA1, hnRNPA2 and PTB. Provided are methods to identify agents which reduce the levels of hnRNPA1, hnRNPA2 or PTB. Provided are methods to identify agents which increase ratio of PKM1/PKM2 proteins, or reduce PKM2 levels, or increase PKM1 levels.
Public/Granted literature
- US20130203835A1 INHIBITORY RNAS TO RNA BINDING PROTEINS HNRNPA1, HNRNPA2 AND PTB AND USES THEREOF Public/Granted day:2013-08-08
Information query
