Invention Grant
- Patent Title: Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
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Application No.: US13731492Application Date: 2012-12-31
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Publication No.: US09206430B2Publication Date: 2015-12-08
- Inventor: Ekambar R. Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
- Applicant: Idera Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee: Idera Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph C. Zucchero; Carolyn S. Elmore, Esq.
- Main IPC: C12N15/117
- IPC: C12N15/117 ; A61K48/00 ; A61K39/00
Abstract:
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
Public/Granted literature
- US20130267583A1 IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE Public/Granted day:2013-10-10
Information query
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