Invention Grant
US09206435B2 Crowding agent-induced nucleic acid transfer into a recipient host cell
有权
拥挤剂诱导的核酸转移到受体宿主细胞中
- Patent Title: Crowding agent-induced nucleic acid transfer into a recipient host cell
- Patent Title (中): 拥挤剂诱导的核酸转移到受体宿主细胞中
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Application No.: US14015070Application Date: 2013-08-30
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Publication No.: US09206435B2Publication Date: 2015-12-08
- Inventor: Bogumil J. Karas , Hutchison Clyde A., III , Hamilton O. Smith , Yo Suzuki
- Applicant: Synthetic Genomics, Inc.
- Applicant Address: US CA La Jolla
- Assignee: Synthetic Genomics, Inc.
- Current Assignee: Synthetic Genomics, Inc.
- Current Assignee Address: US CA La Jolla
- Agency: DLA Piper LLP (US)
- Main IPC: C12N15/81
- IPC: C12N15/81 ; C12N15/87
Abstract:
The presently disclosed invention relates to methods of transferring large nucleic acid molecules or a genome from one cell (the donor) into heterologous host cells in the presence of a crowding agent. The method allows for greater ease and efficiency of transfer of genetic material. Introduction of the donor genetic material into the recipient host cells also allows for manipulation of the donor nucleic acid molecule or genome within the host cells. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.
Public/Granted literature
- US20140179001A1 CROWDING AGENT-INDUCED NUCLEIC ACID TRANSFER INTO A RECIPIENT HOST CELL Public/Granted day:2014-06-26
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