Invention Grant
US09206479B2 Methods and compositions related to Staufen 1 binding sites formed by duplexing Alu elements
有权
与通过双相Alu元件形成的Staufen 1结合位点相关的方法和组合物
- Patent Title: Methods and compositions related to Staufen 1 binding sites formed by duplexing Alu elements
- Patent Title (中): 与通过双相Alu元件形成的Staufen 1结合位点相关的方法和组合物
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Application No.: US13984709Application Date: 2012-02-09
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Publication No.: US09206479B2Publication Date: 2015-12-08
- Inventor: Lynne E. Maquat , Chenguang Gong
- Applicant: Lynne E. Maquat , Chenguang Gong
- Applicant Address: US NY Rochester
- Assignee: University of Rochester
- Current Assignee: University of Rochester
- Current Assignee Address: US NY Rochester
- Agency: Kilpatrick Townsend & Stockton, LLP
- International Application: PCT/US2012/024534 WO 20120209
- International Announcement: WO2012/109476 WO 20120816
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K48/00 ; C07H21/02 ; C07K14/47
Abstract:
Disclosed are compositions and methods for identifying binding sites of targets of Stau1-mediated mRNA decay; methods and compositions for treating subjects with conditions resulting from Stau1-mediated mRNA decay, and method of screening for therapeutic agents. Also disclosed is the new pathway as a means for cells to down-regulate the expression of Stau1-binding mRNAs.
Public/Granted literature
- US20130317087A1 METHODS AND COMPOSITIONS RELATED TO STAUFEN 1 BINDING SITES FORMED BY DUPLEXING ALU ELEMENTS Public/Granted day:2013-11-28
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