A vapor-permeable shoe with waterproof and vapor-permeable sole, including: an upper assembly; a sole joined to the upper assembly and including a body made of waterproof material including a tread and at least one region permeable to water vapor; a waterproof and vapor-permeable membrane, which covers the region, toward an inside of the shoe; a protective element, which covers at least partially the lower face of the membrane; and at least one waterproof and vapor-permeable protective screen superimposed, toward the inside of the shoe, on the membrane to cover it at least partially, the protective screen and the membrane being sealed in a waterproof manner to the body of the sole at at least one sealing zone peripheral to the region.