Invention Grant
US09226673B2 Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
有权
方法，系统和计算机程序产品，用于使用斑点成像技术和血液动力学模型非侵入性确定血流分布
- Patent Title: Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling
- Patent Title (中): 方法，系统和计算机程序产品，用于使用斑点成像技术和血液动力学模型非侵入性确定血流分布
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Application No.: US13833862Application Date: 2013-03-15
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Publication No.: US09226673B2Publication Date: 2016-01-05
- Inventor: Thomas Bruce Ferguson, Jr. , Xin-Hua Hu , Cheng Chen
- Applicant: East Carolina University
- Applicant Address: US NC Greenville
- Assignee: East Carolina University
- Current Assignee: East Carolina University
- Current Assignee Address: US NC Greenville
- Agency: Myers Bigel Sibley & Sajovec
- Main IPC: A61B6/00
- IPC: A61B6/00 ; A61B5/026 ; A61B5/00 ; A61B5/02 ; G02B27/48 ; G06T7/00
Abstract:
Non-invasive methods for determining blood flow distribution in a region of interest are provided. The method includes illuminating a region of interest of a subject with a coherent light source; sequentially acquiring at least two speckle images of the region of interest, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image, determine distribution of blood flow speed in principal vessels and quantify perfusion distribution in tissue in the region of interest from the LSCI image. The LSCI image enables detection of different blood flow speeds.
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