Invention Grant
- Patent Title: Pyrrolidine derivatives
- Patent Title (中): 吡咯烷衍生物
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Application No.: US13779780Application Date: 2013-02-28
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Publication No.: US09226916B2Publication Date: 2016-01-05
- Inventor: Henner Knust , Andreas Koblet , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
- Applicant: Henner Knust , Andreas Koblet , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
- Applicant Address: US NJ Nutley
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Nutley
- Priority: EP09179228 20091215
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D401/06 ; A61K31/40 ; C07D207/14 ; C07D403/06 ; C07D405/06 ; C07D407/04 ; C07D413/06 ; C07D417/14 ; A61K31/4025 ; A61K31/454 ; A61K31/4545 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/5377
Abstract:
The present invention relates to compounds of formula wherein R1, R2, R3, R4, Z, and n are as defined herein or to a pharmaceutically active salt thereof. Compounds of the invention are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
Public/Granted literature
- US20130184249A1 PYRROLIDINE DERIVATIVES Public/Granted day:2013-07-18
Information query
IPC分类:
