Invention Grant
US09226918B2 Methods and compositions for treating or preventing narcotic withdrawal symptoms
有权
用于治疗或预防麻醉戒断症状的方法和组合物
- Patent Title: Methods and compositions for treating or preventing narcotic withdrawal symptoms
- Patent Title (中): 用于治疗或预防麻醉戒断症状的方法和组合物
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Application No.: US12631628Application Date: 2009-12-04
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Publication No.: US09226918B2Publication Date: 2016-01-05
- Inventor: Gary Peltz , David Clark , Lawrence Chu
- Applicant: Gary Peltz , David Clark , Lawrence Chu
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent David J. Aston
- Main IPC: A61K31/485
- IPC: A61K31/485 ; A61K31/4178 ; A61K31/444 ; A61K31/495
Abstract:
This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.
Public/Granted literature
- US20100144754A1 Methods and Compositions for Treating or Preventing Narcotic Withdrawal Symptoms Public/Granted day:2010-06-10
Information query
IPC分类:
