Invention Grant
- Patent Title: Spirocyclic molecules as protein kinase inhibitors
- Patent Title (中): 螺环分子作为蛋白激酶抑制剂
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Application No.: US14234586Application Date: 2012-07-26
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Publication No.: US09226923B2Publication Date: 2016-01-05
- Inventor: Zhaoyin Wang , Lianhai Li , Zhigang Wang
- Applicant: Zhaoyin Wang , Lianhai Li , Zhigang Wang
- Applicant Address: CN Nanjing
- Assignee: Nanjing Allgen Pharma Co. Ltd.
- Current Assignee: Nanjing Allgen Pharma Co. Ltd.
- Current Assignee Address: CN Nanjing
- Agency: Kilpatrick, Townsend & Stockton LLP
- International Application: PCT/CA2012/000709 WO 20120726
- International Announcement: WO2013/013308 WO 20130131
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/4439 ; A61K45/06
Abstract:
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers. R2 is selected from
Public/Granted literature
- US20140243303A1 SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS Public/Granted day:2014-08-28
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