Invention Grant
- Patent Title: Histone inhibition
- Patent Title (中): 组蛋白抑制
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Application No.: US13990031Application Date: 2011-11-29
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Publication No.: US09226939B2Publication Date: 2016-01-05
- Inventor: Ross Wentworth Stephens , Christopher Richard Parish , Craig Geoffrey Freeman , Timothy John Senden
- Applicant: Ross Wentworth Stephens , Christopher Richard Parish , Craig Geoffrey Freeman , Timothy John Senden
- Applicant Address: AU Acton, Australian Capital Territory
- Assignee: THE AUSTRALIAN NATIONAL UNIVERSITY
- Current Assignee: THE AUSTRALIAN NATIONAL UNIVERSITY
- Current Assignee Address: AU Acton, Australian Capital Territory
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/AU2011/001550 WO 20111129
- International Announcement: WO2012/071611 WO 20120607
- Main IPC: A61K31/737
- IPC: A61K31/737 ; A61K31/7016 ; A61K31/702 ; A61K31/727 ; A61K31/70 ; A61K31/715 ; A61K31/724
Abstract:
The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.
Public/Granted literature
- US20130338097A1 HISTONE INHIBITION Public/Granted day:2013-12-19
Information query
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