Invention Grant
US09226949B2 FGF-18 truncated variants having increased receptor specificity and uses thereof
有权
具有增加的受体特异性的FGF-18截短变体及其用途
- Patent Title: FGF-18 truncated variants having increased receptor specificity and uses thereof
- Patent Title (中): 具有增加的受体特异性的FGF-18截短变体及其用途
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Application No.: US13848569Application Date: 2013-03-21
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Publication No.: US09226949B2Publication Date: 2016-01-05
- Inventor: Avner Yayon , Eran Rom , Roy Sirkis , Dalit Strauss-Ayali
- Applicant: HEPACORE LTD.
- Applicant Address: IL Ness Ziona
- Assignee: HEPACORE LTD.
- Current Assignee: HEPACORE LTD.
- Current Assignee Address: IL Ness Ziona
- Agency: Vorys, Sater, Seymour and Pease LLP
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; A61K45/06
Abstract:
The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.
Public/Granted literature
- US20130225493A1 FGF-18 Truncated Variants Having Increased Receptor Specificity And Uses Thereof Public/Granted day:2013-08-29
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