Invention Grant
- Patent Title: Variants of plasminogen and plasmin
- Patent Title (中): 纤溶酶原和纤溶酶的变体
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Application No.: US13383086Application Date: 2010-07-09
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Publication No.: US09226953B2Publication Date: 2016-01-05
- Inventor: Richard Reinier Zwaal
- Applicant: Richard Reinier Zwaal
- Applicant Address: BE Leuven
- Assignee: ThromboGenics NV
- Current Assignee: ThromboGenics NV
- Current Assignee Address: BE Leuven
- Agency: Fish & Richardson P.C.
- Priority: EP09165237 20090710
- International Application: PCT/EP2010/059902 WO 20100709
- International Announcement: WO2011/004011 WO 20110113
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/48 ; C12N9/68
Abstract:
The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatylic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.
Public/Granted literature
- US20120114630A1 VARIANTS OF PLASMINOGEN AND PLASMIN Public/Granted day:2012-05-10
Information query
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