Invention Grant
- Patent Title: Immunization against Clostridium difficile disease
- Patent Title (中): 针对艰难梭菌病的免疫
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Application No.: US13457821Application Date: 2012-04-27
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Publication No.: US09226956B2Publication Date: 2016-01-05
- Inventor: William D. Thomas, Jr. , Paul J. Giannasca , Zhenxi Zhang , Wende Lei , Thomas P. Monath
- Applicant: William D. Thomas, Jr. , Paul J. Giannasca , Zhenxi Zhang , Wende Lei , Thomas P. Monath
- Applicant Address: US MA Cambridge
- Assignee: Sanofi Pasteur Biologics, LLC
- Current Assignee: Sanofi Pasteur Biologics, LLC
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Agent Susan M. Michaud
- Main IPC: A61K39/08
- IPC: A61K39/08 ; A61K39/02 ; A61K39/40 ; A61K39/00 ; A61K39/38 ; C07K14/33 ; C07K16/12
Abstract:
The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
Public/Granted literature
- US20130177592A1 IMMUNIZATION AGAINST CLOSTRIDIUM DIFFICILE DISEASE Public/Granted day:2013-07-11
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