Invention Grant
- Patent Title: Salt form of a multi-arm polymer-drug conjugate
- Patent Title (中): 盐形式的多臂聚合物 - 药物缀合物
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Application No.: US13510587Application Date: 2010-11-18
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Publication No.: US09226969B2Publication Date: 2016-01-05
- Inventor: Anthony O. Chong , Seoju Lee , Bhalchandra V. Joshi , Brian Bray , Shaoyong Nie , Patrick L. Spence , Antoni Kozlowski , Samuel P. McManus , Sachin Tipnis , Greg Lavaty , David Swallow , John R. Handley , Anthony G. Schaefer
- Applicant: Anthony O. Chong , Seoju Lee , Bhalchandra V. Joshi , Brian Bray , Shaoyong Nie , Patrick L. Spence , Antoni Kozlowski , Samuel P. McManus , Sachin Tipnis , David Swallow , John R. Handley , Anthony G. Schaefer
- Applicant Address: US CA San Francisco
- Assignee: Nektar Therapeutics
- Current Assignee: Nektar Therapeutics
- Current Assignee Address: US CA San Francisco
- Agent Mark A. Wilson; Susan T. Evans
- International Application: PCT/US2010/057292 WO 20101118
- International Announcement: WO2011/063158 WO 20110526
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; C07D491/22 ; A61K47/48 ; C08G65/329 ; C08G65/333 ; C07C51/41 ; C07C53/18 ; C08G65/48
Abstract:
Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate.
Public/Granted literature
- US20130231359A1 Salt Form of a Multi-Arm Polymer-Drug Conjugate Public/Granted day:2013-09-05
Information query
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