Invention Grant
- Patent Title: PSMA-binding agents and uses thereof
- Patent Title (中): PSMA结合剂及其用途
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Application No.: US14211683Application Date: 2014-03-14
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Publication No.: US09226981B2Publication Date: 2016-01-05
- Inventor: Martin G. Pomper , Ronnie Charles Mease , Ying Chen
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Ward and Smith, P.A.
- Agent Jeffrey W. Childers
- Main IPC: A61K51/00
- IPC: A61K51/00 ; C07C275/18 ; A61K51/04 ; A61K9/127 ; C07C275/16 ; C07D213/61 ; C07D213/74 ; C07D213/82 ; C07F7/22
Abstract:
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
Public/Granted literature
- US20140369931A1 PSMA-BINDING AGENTS AND USES THEREOF Public/Granted day:2014-12-18
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