A catheter connector and method of use is disclosed. The catheter connector includes a body, a proximal end port, and a seal. The body has a proximal end and a distal end. Further, the body defines a hollow interior from the proximal end to the distal end. The hollow interior is configured to receive a catheter at least partially therethrough. The proximal end port includes a cavity and is configured with the proximal end of the body for mating communication with a fluid delivery device, such as a pump, reservoir, syringe, or the like. This port may have any conventional configuration, such as a Luer-lock fitting. The seal is configured within the interior of the body and includes a passage configured for receipt of the catheter. In addition, at least a portion of the seal is configured within the cavity of the proximal end port. Further, the seal is configured to compress around the catheter so as to axially secure the catheter within the body.