A clothes dryer vent coupling system for connecting the vent outlet of a clothes dryer to an exhaust pipe in a room wall includes a rectangular housing secured to the wall and includes sides and a front wall. An outlet coupling on one side of the housing is connected to the exhaust pipe through rigid or flexible tubing. The front wall of the housing includes a round inlet opening facing forward. A connector coupling connected to the vent outlet at the back of the clothes dryer has a conical end but with openings therein. When the dryer is moved toward the room wall, the connector coupling is guided into and enters the inlet opening. Once in place, a rubber gasket around the connector coupling seals the coupling to the housing.