A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.