A vehicle frame structure includes a pair of hat-shaped panels that form a portion of a vehicle, each hat-shaped panel having a hat-shaped cross-section, the pair of hat-shaped panels facing each other and forming a closed sectional portion; a partition panel that is sandwiched by the pair of hat-shaped panels, and divides an inside of the closed sectional portion; and a laser welded portion where all of four or more plates including the pair of hat-shaped panels and the partition panel are overlapped and welded together at an identical position by laser welding.