A theft-proof packaging system includes a product package having a compartment configured to encapsulate a product, wherein the compartment is pneumatically pressurized above a surrounding environment. A pressure sensor assembly is located within the compartment. The pressure sensor assembly includes a pressure sensor, a power source electrically connected to the pressure sensor and a transmitter electrically connected to the power source. The transmitter is configured to send a signal. A receiving unit is located outside the compartment of the product package and disposed remote from the product package. The receiving unit includes a receiver configured to receive the signal from the transmitter and an alarm electrically coupled to the receiver. The pressure sensor assembly is configured to detect a change in pressure inside the compartment and then send the signal to the receiving unit activating the alarm.